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chemically induced dimerization
Chemically Induced Dimerization (CID) is a biological mechanism in which two proteins bind only in the presence of a certain small molecule, enzyme or other dimerizing agent. Genetically engineered CID systems are used in biological research to control protein localization, to manipulate signalling pathways and to induce protein activation.
==History==
The first small molecule CID system, developed in 1993, used FK1012, a derivative of the drug FK506, to induce homo-dimerization of FKBP. This system was used ''in vivo'' to induce binding between cell surface receptors which could not bind in the normal way because they lacked transmembrane and extracellular domain. Addition of FK1012 to the cells caused signal transduction.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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